Developments in nanotechnology, electronics, computing, algorithms, imaging, and fabrication technologies are assisting us in miniaturizing optical/photonic devices to become portable and suitable for point of care and field applications. During the last 10 years we have been working on different technologies for this purpose including full field optical coherence tomography, plasmonic sensors, and spectral/polarization control liquid crystal devices.

In this lecture I will review our miniaturized devices developed for these purposes including spectro-polarimetric imaging module based on unique liquid crystal devices demonstrated for skin cancer detection, plasmonic sensor with less than 1kg weight and small form factor demonstrated for detecting biomarkers, viruses, bacteria and other analytes, SERS sensors with ultrahigh enhancement, and more.

Selected publications:

1. Lior Graham, Yitzhak Yitzhaky and I. Abdulhalim, Classification of skin moles from optical spectro-polarimetric images, J. Biomed. Optics 18, 111403 (2013).
2. Sachin K. Srivastava, Atef Shalabney, I. Khalailah, Christoph Grüner, B. Rauschenbach, and I. Abdulhalim, SERS Biosensor using Metallic nanoSculptured Thin Films for the Detection of Endocrine Disrupting Compound Biomarker Vitellogenin, Small 10, 3579-3587 (2014).
3. Avner Safrani and Ibrahim Abdulhalim, High speed 3D imaging using two wavelengths parallel phase shift interferometry, Optics Letters 40, 4651-4 (2015).
4. Michael Ney and I. Abdulhalim, Ultrahigh polarimetric image contrast enhancement for skin cancer diagnosis using InN plasmonic nanoparticles in the THz range, J. Biomed. Optics 20, 125007(14p) (2015).
5. Sachin K. Srivastava, Christoph Gruner, Dietmar Hirsch, Bernd Rauschenbach, Ibrahim Abdulhalim, Enhanced intrinsic fluorescence from carboxidized nano-sculptured thin films of silver and their application for label free dual detection of glycated hemoglobin, Optics Express 25, 4761-72 (2017).
6. Andrey Nazarov, Boris Knyazer, Tova Lifshitz, Mark Schvartzman, Ibrahim Abdulhalim, Assessment of intraocular pressure sensing using an implanted reflective flexible membrane, J. Biomed. Opt., 22(4), 047001 (2017).
7. Marwan J. Abuleil and Ibrahim Abdulhalim, Broadband ellipso-polarimetric camera utilizing tunable liquid crystal achromatic waveplate with improved field of view, Optics Express 27 (9) 12011-24 (2019).
8. Dorin Harpaz, Brescia Koh, Robert S. Marks, Raymond C. S. Seet, Ibrahim Abdulhalim and Alfred I. Y. Tok, Point-of-Care Surface Plasmon Resonance Biosensor for Stroke Biomarkers NT-proBNP and S100β using a Functionalized Gold Chip with Specific Antibody, Sensors, 19, 2533(16p) (2019).
9. Aabha Bajaj, Anand M. Shrivastav, Evgeny Eltzov, Noam Alkan, and Ibrahim Abdulhalim, Detection of necrotrophic DNA marker of anthracnose causing Colletotrichum gloeosporioides fungi in harvested produce using surface plasmon resonance, Talanta 235, 122776 (2021).